ChinaChao Rong 1,two, *, Hai-Feng Jiang 3 , Rui-Wen Zhang 4 , Li-Juan Zhang four , Jian-Chen Zhang five , Jing

Results: Log-rank test results showed that the cumulative relapse rate variations among 4 MLN1117 groups throughout the two-year follow-up period weren't statistically significant (two = five.889, p = 0.117). Res.ChinaChao Rong 1,2, *, Hai-Feng Jiang three , Rui-Wen Zhang four , Li-Juan Zhang 4 , Jian-Chen Zhang 5 , Jing Zhang 6 and Xue-Shan Feng 1,1 2 three four five 6*School of Public Health, Fudan University, Shanghai 200032, China; xsfeng@shmu.edu.cn School of Humanities and Social Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China Shanghai Mental Health Center, Shanghai 200030, China; rcnj2008@163.com Technological and Industrial Promotion Center of Traditional Chinese Medicine, Shanghai 201203, China; guanlishui@126.com (R.-W.Z.); zhanglj@biopham.sh.cn (L.-J.Z.) Drug Handle Workplace, Shanghai 200129, China; zhangjc88@sina.com The Council of Shanghai Ziqiang Social Solutions, Shanghai 200030, China; isurevictory@163.com Important Laboratory of Public Overall health Safety, Ministry title= journal.pone.0073519 of Education, Shanghai 200032, China Correspondence: 12111020023@fudan.edu.cn; Tel.: +86-571-8661-Academic Editors: Amie Hayley and Joris Cornelis Verster Received: 30 November 2015; Accepted: 25 January 2016; Published: 28 JanuaryAbstract: Background: Lots of countries including China are facing a really serious opiate dependence difficulty. Anti-drug operate effectiveness was impacted by the high relapse rate around the globe. This study aims to analyze the aspects influencing heroin addict relapse, and to provide proof for generating relapse prevention techniques. Methods: A community-based follow-up study was conducted in China involving October 2010 and September 2012. A total of 554 heroin addicts in accordance with all the inclusion criteria from 81 streets in 12 districts of Shanghai, China were divided into four groups: group 1--daily dosage taken orally of 60 mL of methadone or beneath combined with psychological counseling and social supports (n = 130); group 2--daily dosage taken orally of over 60 mL of methadone combined with psychological counseling and social supports (n = 50); group 3--JTT (Jitai tablets) combined with psychological counseling and social supports (n = 206); group 4--JTT combined with social supports (n = 168). Final results: Log-rank test results showed that the cumulative relapse price variations among four groups during the two-year follow-up period weren't statistically substantial (2 = five.889, p = 0.117). Multivariate Cox regression analysis final results showed that only 3 independent variables had been nevertheless statistically important, including compliance with participation in psychological counseling (OR = three.563, p = 0.000), the years of drug use (OR = 1.078, p = 0.001)and intervention model. Conclusions: Employing the detoxification drugs combined with appropriate psychological counseling and social help measures will aid increase the effectiveness of relapse prevention, which is a type of option neighborhood detoxification pattern. Proper and standard title= rstb.2014.0252 psychological counseling is extremely crucial for anti-drug therapy. The longer the drug addiction lasts, the longer the anti-drug therapy takes. Keywords: community-based drug treatment; methadone; Jitai tablets; psychological counseling; follow-up study1. Introduction Quite a few nations are facing a really serious issue with opiate dependence. Based on a report title= 2750858.2807526 by the United Nations Office on Drugs and Crime (UNODC) from the Chinese Ministry of Public Safety in 2014, global drug trafficking has involved greater than 170 nations and regions with an annual drugInt. J.