0.90 Sp= 0.75 LC 2 Se= 0.75 Sp= 0.LC 1 Se= 0.90 Sp= 0.75 LC 2 Se= 0.90 Sp= 0.LC

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BMC Health-related Analysis Methodology 2014, 14:88 http://www.biomedcentral.com/1471-2288/14/Page 6 of100 80100 80100 80100 80100 80100 80010 25 50010 25 50010 25 50010 25 50010 25 50010 25 50LC 1 Se= 0.90 Sp= 0.75 LC two Se= 0.75 Sp= 0.LC 1 Se= 0.90 Sp= 0.75 LC 2 Se= 0.90 Sp= 0.LC 1 Se= 0.90 Sp= 0.75 LC 2 Se= 0.75 Sp= 0.LC 1 Se= 0.90 Sp= 0.60 LC two Se= 0.60 Sp= 0.LC 1 Se= 0.90 Sp= 0.60 LC 2 Se= 0.90 Sp= 0.LC 1 Se= 0.90 Sp= 0.60 LC two Se= 0.60 Sp= 0.one hundred 80100 80100 80100 80100 80100 80000000LC 1 Se= 0.90 Sp= 0.75 LC two Se= 0.75 Sp= 0.LC 1 Se= 0.90 Sp= 0.75 LC 2 Se= 0.90 Sp= 0.LC 1 Se= 0.90 title= jasp.12117 Sp= 0.75 LC two Se= 0.75 Sp= 0.LC 1 Se= 0.90 Sp= 0.60 LC two Se= 0.60 Sp= 0.LC 1 Se= 0.90 Sp= 0.60 LC two Se= 0.90 Sp= 0.LC 1 Se= 0.90 Sp= 0.60 LC 2 Se= 0.60 Sp= 0.Figure three Simulation outcomes for median within-study sample size equals to 40 (major panel) and 500 (bottom panel). Power of LCBM (proportion of replications in which the LCBM is preferred over the BM when data are generated following a true latent class structure) when it comes to AIC (strong line) AIC3 (dotted line) and BIC (dashed line).100 80100 80100 80010 25 50010 25 50010 25 50Se= 0.90 Sp= 0.Se= 0.90 Sp= 0.Se= 0.90 Sp= 0.100 80100 80100 80010 25 50010 25 50010 25 50Se= 0.90 Sp= 0.Se= 0.90 Sp= 0.Se= 0.90 Sp= 0.Figure 4 Simulation final results for median within-study size equals to 40 (prime panel) and 500 (bottom panel). Confidence of LCBM (proportion of replications in which the BM is preferred over the LCBM when information are generated within a single class structure) when it comes to AIC (strong line) AIC3 (dotted line) and BIC (dashed line).Eusebi et al. BMC Medical Investigation Methodology 2014, 14:88 http://www.biomedcentral.com/1471-2288/14/Page 7 ofa single class model. AIC and AIC3 were reliable criteria, up to a certain quantity of research (about up to 25 research for AIC and 50 for AIC3).Actual data example: coronary artery disease dataWe illustrate the usage of the LCBM method by reanalyzing information from Schuetz and other individuals [29]. This wellknown dataset is presented (Extra file 1) inside the Cochrane Handbook for Systematic Reviews of Diagnostic Test Accuracy [16]. In this meta-analysis, the diagnostic performances of multislice computed tomography (CT) and magnetic resonance imaging (MRI) for the diagnosis of coronary artery illness (CAD) are compared. Prospective Very same time we've got demonstrated that radiationFig. six. Radiation combined with anti-PD- studies that evaluated either CT or MRI (or both), made use of conventional coronary angiography (CAG) because the reference common, and utilized exactly the same threshold for clinically considerable coronary artery stenosis (a diameter reduction of 50 or more) had been included within the critique. A total of 103 studies offered a 2-by-2 table for one or both tests and had been included in.