An be explained by 4E6's high affinity for solubilized PHF

Antibodies with access to both intra- and extracellular pools of pathological tau protein are likely to be more title= fpsyg.2016.01503 U0126 site efficacious than antibodies acting only within one compartment.ResultsIn vivo studies 4E6 acutely improves cognition in htau mice and reduces soluble phospho-tau protein, whereas 6B2 does not affect cognition or tau levelsAt 11?2 months of age, the htau mice were assigned to control and treatment groups with similar cognitive (CFSM test) and motor status (Rotorod and Open Field). pre-test; 13.6 (average errors) ?1.2 (SEM) to 7.1 ?0.9, p title= fnins.2013.00232 Closed Field Symmetrical (CFS) Maze (48 fewer errors, p title= fpsyg.2016.01503 efficacious than antibodies acting only within one compartment.ResultsIn vivo studies 4E6 acutely improves cognition in htau mice and reduces soluble phospho-tau protein, whereas 6B2 does not affect cognition or tau levelsAt 11?2 months of age, the htau mice were assigned to control and treatment groups with similar cognitive (CFSM test) and motor status (Rotorod and Open Field).