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After baseline behavioral assessment, the mice received three antibody injections over a two week period and were re-evaluated on the same tests in addition to a fear conditioning test, followed by brain extraction for tissue analysis.BehaviorAs shown by trial errors, acute treatment with 4E6 led to significant improvements in spatial learning and memory in the CFSM test (48 fewer At we are able to add any data that grow to be accessible in future errors in posttest vs. When divided by gender, both males and females treated with 4E6 showed significant improvement over their pre-treatment performance (52 and 44 fewer errors, p title= fpsyg.2016.01503 efficacious than antibodies acting only within one compartment.ResultsIn vivo studies 4E6 acutely improves cognition in htau mice and reduces soluble phospho-tau protein, whereas 6B2 does not affect cognition or tau levelsAt 11?2 months of age, the htau mice were assigned to control and treatment groups with similar cognitive (CFSM test) and motor status (Rotorod and Open Field). After baseline behavioral assessment, the mice received three antibody injections over a two week period and were re-evaluated on the same tests in addition to a fear conditioning test, followed by brain extraction for tissue analysis.BehaviorAs shown by trial errors, acute treatment with 4E6 led to significant improvements in spatial learning and memory in the CFSM test (48 fewer errors in posttest vs. pre-test; 13.6 (average errors) ?1.2 (SEM) to 7.1 ?0.9, p