Bearbeiten von „Can also regulate the expression and/or function of other genes.“

2008; Congrains et al. 2013), mRNA stabilization (Mahmoudi et al. 2009; Su et al. 2012), alternative splicing (Morrissy et al. 2011), or post-translational regulation among others. The role of dysregulated [http://www.playminigamesnow.com/members/shrine68lamb/activity/670232/ By antisense transcriptsRecent research with gene pairs from bidirectional promoters have] antisense transcript expression has been investigated in [https://www.autotrader.com/?LNX=DRMEDADTECHHP77 Title Loaded From File] neurological illnesses such as Alzheimer's disease (Faghihi et al. 2008), schizophrenia (Millar et al. 2000), [https://dx.doi.org/10.1371/journal.pone.0158910 title= journal.pone.0158910] Parkinson's disease (Scheele et al. 2007), and in multiple cancers (Luo et al. 2006; Huarte et al. 2010; Geng et al. 2011; Kogo et al. 2011; Prensner et al. 2011; Schmidt et al. 2011; Silva et al. 2011; Niinuma et al. 2012; Han et al. 2013; Kim et al. 2013b). Previous studies of antisense expression often assessed only a small fraction of the transcriptome largely missing low-expressed transcripts, primarily due to methodological limitations including low accuracy and transcriptome coverage (Katayama et al. 2005;?2015 Balbin et al. This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.These authors contributed equally to this work. These authors share senior authorship. Corresponding authors: arul@umich.edu, nesvi@med.umich.edu Article published online before print. Article, supplemental material, and publication date are at http://www.genome.org/cgi/doi/10.1101/gr.180596.114.Genome Researchwww.genome.org25:1068?079 Published by Cold Spring Harbor Laboratory Press; ISSN 1088-9051/15; www.genome.orgLandscape of antisense gene expression in cancerHe et al. 2008). Antisense transcript detection and assessment, especially in cancer, is hampered by the small data sets ([https://dx.doi.org/10.4137/SART.S23506 title= SART.S23506] Zhang et al. 2009), silencing (Yu et al.