Can also regulate the expression and/or function of other genes.

2008; Congrains et al. 2013), mRNA stabilization (Mahmoudi et al. 2009; Su et al. 2012), alternative splicing (Morrissy et al. 2011), or post-translational regulation among others. The role of dysregulated By antisense transcriptsRecent research with gene pairs from bidirectional promoters have antisense transcript expression has been investigated in Title Loaded From File neurological illnesses such as Alzheimer's disease (Faghihi et al. 2008), schizophrenia (Millar et al. 2000), title= journal.pone.0158910 Parkinson's disease (Scheele et al. 2007), and in multiple cancers (Luo et al. 2006; Huarte et al. 2010; Geng et al. 2011; Kogo et al. 2011; Prensner et al. 2011; Schmidt et al. 2011; Silva et al. 2011; Niinuma et al. 2012; Han et al. 2013; Kim et al. 2013b). Previous studies of antisense expression often assessed only a small fraction of the transcriptome largely missing low-expressed transcripts, primarily due to methodological limitations including low accuracy and transcriptome coverage (Katayama et al. 2005;?2015 Balbin et al. This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.These authors contributed equally to this work. These authors share senior authorship. Corresponding authors: arul@umich.edu, nesvi@med.umich.edu Article published online before print. Article, supplemental material, and publication date are at http://www.genome.org/cgi/doi/10.1101/gr.180596.114.Genome Researchwww.genome.org25:1068?079 Published by Cold Spring Harbor Laboratory Press; ISSN 1088-9051/15; www.genome.orgLandscape of antisense gene expression in cancerHe et al. 2008). Antisense transcript detection and assessment, especially in cancer, is hampered by the small data sets (title= SART.S23506 Zhang et al. 2009), silencing (Yu et al.