Lung and bone, and multiple metastases. The results showed that for

Green line: Cumulative disease-free survival curve of the 116 patients with TACE R848 cost before LT; Blue line: Cumulative diseasefree survival curve of the 88 patients without TACE before LT. TACE, liver transplantation, poor prognostic, HCCTable 5 Tumor recurrence and metastasis in the groups with and without transarterial chemoembolizationTACE Liver Milan criteria UCSF criteria BUCSF criteriaaNo TACE Bone 0 0 0 M 2 2 8 Liver 1 1 5 Lung 3 3 3 Bone 0 0 1 M 1 20.019 j.jebo.2013.04.005 2.083 10.P value0.990 0.353 0.get Duvoglustat 015aLung 7 72 0P 0.05). As seen in Table 5, the number of cases with pulmonary and distant metastasis in the TACE groups was higher than that of the groups without TACE.0.DISCUSSIONLT as a curative and effective therapy for HCC can remove the tumor and cirrhosis of the liver tissue and avoid malignant changes in residual disease in [17,18] liver tissue . However, whether TACE before LT is suitable for patients with HCC is still controversial. Grasso and others have suggested that preoperative adjuvant therapy has no effect on the recurrence rate [19] [20] when the Milan criteria are not followed . Yao et al have proposed that proper preoperative treatment is necessary for patients exceeding the Milan criteria. Roayaie and others have suggested that preoperative TACE combined with postoperative doxorubicin chemotherapy has satisfactory therapeutic effects for [21] large liver cancers and LT . Aggressive preoperative treatment may have a positive role in reducing neoplasm stage, and thus reduce the rate of tumor recurrence. Our results suggest that sex, MELD score, Child classification, surgical approach, postoperative complications, and other general clinical data in the groups with and without TACE made no significant difference. The 1-, 3- and 5-year cumulative survival rates of the patients with and without TACE were 2 significantly different ( = 22.547, P 0.05). As seen in Table 5, the number of cases with pulmonary and distant metastasis in the TACE groups was higher than that of the groups without TACE.0.DISCUSSIONLT as a curative and effective therapy for HCC can remove the tumor and cirrhosis of the liver tissue and avoid malignant changes in residual disease in [17,18] liver tissue . However, whether TACE before LT is suitable for patients with HCC is still controversial. Grasso and others have suggested that preoperative adjuvant therapy has no effect on the recurrence rate [19] [20] when the Milan criteria are not followed . Yao et al have proposed that proper preoperative treatment is necessary for patients exceeding the Milan criteria.