Harest, Romania; 4 Faculty of Dental Medicine, Ovidius University, Constana, Romania Correspondence

Relating to the comparison of your two procedures APRI and FIB-4 Kappa = 0.217, 95 CI (-0.424, 0.858), which confirms the low correlation. Conclusions There is some proof that the tests made use of: APRI and FIB-4 have the capacity to distinguish for each groups of individuals (HIV and HIV/HBV) between the two classes of fibrosis (F0-1 to F 2), patients title= journal.pone.0092276 with and with out advanced liver illness. While in sufferers with HIV infection a low concordance was noticed involving non-invasive procedures for the diagnosis of fibrosis, in co-infected patients it was moderate and these tests could be utilized as evaluation methods in their monitoring of liver injury specifically when the outcomes of those tests are concordant. A53 Undetectable HIV viral load ?the primary goal in the management of HIV-infected individuals Carmen Chiriac, Nina-Ioana Bodnar, Iringo-Erzsebet Zaharia-Kezdi, Cristina G bovan, Andrea Incze, Anca Meda Georgescu University of Medicine and Pharmacy T gu Mure, T gu Mure, Romania Correspondence: Nina-Ioana Bodnar (ninasincu@yahoo.com) BMC Infectious Diseases 2016, 16(Suppl 4):A53 Background Extremely active antiretroviral therapy (HAART) represents the cornerstone within the management of HIV-infected patients, its primary goal ?immune restoration, swiftly achieved and maintained undetectable HIV-RNA viral load. Procedures We performed a retrospective descriptive study which includes the HIVinfected patients in care in Mure county. We chosen all patients who accomplished rapid and long-lasting undetectable HIV-RNA plasma viral load (36 months). We collected information regarding demographic attributes, route of transmission and duration of HIV infection, nadir CD4+ T-cells count, maximum HIV-RNA plasma viral load.Harest, Romania; 4 Faculty of Dental Medicine, Ovidius University, Constana, Romania Correspondence: Elena Dumea (elenadumea@yahoo.com) BMC Infectious Diseases 2016, 16(Suppl four):A52 Background In our country, the prevalence of HIV with hepatitis B virus (HBV) coinfection in young HIV optimistic individuals was high, about 40 . Measurement of liver fibrosis employing (as a noninvasive process) Annual risk for active tuberculosis in these sufferers is five?0 per year transient elastography (TE) in HIV patients might be employed as a tool to establish and monitor hepatic diseases. We evaluated the potential of APRI and FIB-4 score to differentiate among the diverse stages of fibrosis (no fibrosis/minimal fibrosis = F0-1 and F2-4 = moderate-severe fibrosis/ cirrhosis), taking as a reference, in the absence of liver biopsy, hepatic fibrosis stratification by Fibroscan. Approaches We studied a group of individuals infected with HIV (110) and 64.five of those are co-infected HIV/HBV. We determined the cut-off values for APRI and FIB-4 that identify substantial fibrosis with maximum specificity by AUROC for every group. Kappa score was then calculated for the concordance in between strategies. Benefits For HIV/HBV co-infected patients, to identify important fibrosis comparing APRI versus Fibroscan the Kappa score = 0.494, 95 CI (0.245,0.742) on the identification of fibrosis (F0-1 to F two); for FIB-4 versus Fibroscan the Kappa score = 0.481, 95 CI (0.238, 0.725) for both the moderate concordance. Concerning the comparison in the two techniques APRI and FIB-4, Kappa score = 0.698, 95 CI (0.485, 0.910), concordance important. For patients with HIV, to recognize title= pnas.1602641113 considerable fibrosis by APRI versus Fibroscan Kappa = 0.217, 95 CI (-0.424, 0.858) on the identification of fibrosis (F0-1 to F 2), for the FIB-4 Kappa = 0.164, 95 CI (-0.451, 0.779) for each the correlation is reduced.