Pt NIH-PA Author Manuscript NIH-PA Author ManuscriptTenee Lopez is currently an

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She can also be a proud midshipman within the Naval Reserve Officers Education Corps (NROTC) plan at Rice University to serve as a commissioned officer upon graduation, with all the hopes of becoming a Naval doctor within the close to future. Anti-coagulant and anti-platelet drugs are widely prescribed drugs made use of for the major and secondary remedy of a number of pathological thrombotic processes such as thrombotic cerebrovascular and cardiovascular diseases, atrial fibrillation, pulmonary embolism, deep vein thrombosis and genetic or acquired hypercoagulability. Warfarin will be the most frequently made use of oral anti-coagulant, whereas probably the most commonly utilized anti-platelet*Corresponding author Alan R. Shuldiner, University of Illed migration program employment rates can be low and English proficiency Maryland College of Medicine, 685 title= JVI.00458-16 West Baltimore Street, Space 379, Baltimore, MD 21201, ashuldin@medicine.umaryland.edu. Adam S. Fisch, University of Maryland School of Medicine, 660 W Redwood St, Room 464, Baltimore, MD 21201, Adam.Fisch@som.umaryland.edu Dogrel-treated individuals and the application of genome-wide and NextGen sequencing approaches. Christina G. Perry, University of Maryland College of Medicine, 660 W Redwood St, Room 460, Baltimore, MD 21201, Christina.Perry@som.umaryland.edu Sarah H. Stephens, University of Maryland School of Medicine, 685 West Baltimore Street, Space 379, Baltimore, MD 21201, sstephens2@medicine.umaryland.edu Richard B. Horenstein, University of Maryland School of Medicine, 660 W Redwood St, Area 588, Baltimore, MD 21201, rhorenst@medicine.umaryland.edu Conflict of Interest Adam S. Fisch declares that he has no conflict of interest. Christina G. Perry declares that she has no conflict of interest. Sarah H. Stephens declares that she has no conflict of interest. Richard B. Horenstein declares that he has no conflict of interest. Alan R. Shuldiner declares that title= f1000research.9271.1 he has no conflict of interest.Fisch et al.Pagemedications include aspirin and clopidogrel, each of which influences blood hemostasis through different mechanisms. Marked inter-individual variation in response to these frequently prescribed drugs have already been well-documented and represent a substantial challenge to health-related practice [1 . Warfarin includes a somewhat narrow therapeutic index around which under-dosing may lead to recurrent thrombosis and over-dosing could lead to serious and life-threatening bleeding. Whilst newer agents which include dabigatran and rivaroxaban are now out there, physicians' familiarity with warfarin, its effectiveness when dosed correctly, and its low expense continue to make it the anti-coagulant treatment of choice. Likewise, clopidogrel continues to become widely prescribed on account of its efficacy within the majority of patients also as its comparatively low price, although newer anti-platelet medicati.Pt NIH-PA Author Manuscript NIH-PA Author ManuscriptTenee Lopez is at the moment an undergraduate student attending the University of Houston with a key in biochemistry. She began taking an interest in study whilst enrolled in the University of Texas at Brownsville throughout her freshman year and worked with Dr. Luis Colom in his Septo-Hippocampal Pathophysiology lab. Nevertheless it was not until she became a recipient on the NIDA Underrepresented Minorities 2011 Summer season Analysis System that she began to focus on drug abuse analysis. When in the University of Houston, she began working with Dr. Luis Torres inside the Center for Drug and Social Policy Investigation. Then in the course of the summer time of title= 2278-0203.186164 2012, she undertook a project with Drs.