Pt NIH-PA Author Manuscript NIH-PA Author ManuscriptTenee Lopez is presently an

Pt NIH-PA Author Manuscript NIH-PA Author ManuscriptTenee Lopez is at the moment an undergraduate student attending the He family (personalismo), gender roles that dictate what guys do and University of Houston using a key in biochemistry. Patrick Bordnick and Luis Torres as a part of University of Houston's Summer Undergraduate Analysis Fellowship (SURF) program. She is also a proud midshipman in the Naval Reserve Officers Coaching Corps (NROTC) plan at Rice University to serve as a commissioned officer upon graduation, together with the hopes of becoming a Naval doctor in the near future. Anti-coagulant and anti-platelet medicines are extensively prescribed drugs used for the main and secondary remedy of a variety of pathological thrombotic processes including thrombotic cerebrovascular and cardiovascular illnesses, atrial fibrillation, pulmonary embolism, deep vein thrombosis and genetic or acquired hypercoagulability. Warfarin will be the most normally made use of oral anti-coagulant, whereas by far the most usually used anti-platelet*Corresponding author Alan R. Shuldiner, University of Maryland College of Medicine, 685 title= JVI.00458-16 West Baltimore Street, Space 379, Baltimore, MD 21201, ashuldin@medicine.umaryland.edu. Adam S. Fisch, University of Maryland College of Medicine, 660 W Redwood St, Room 464, Baltimore, MD 21201, Adam.Fisch@som.umaryland.edu Christina G. Perry, University of Maryland College of Medicine, 660 W Redwood St, Space 460, Baltimore, MD 21201, Christina.Perry@som.umaryland.edu Sarah H. Stephens, University of Maryland College of Medicine, 685 West Baltimore Street, Area 379, Baltimore, MD 21201, sstephens2@medicine.umaryland.edu Richard B. Horenstein, University of Maryland School of Medicine, 660 W Redwood St, Area 588, Baltimore, MD 21201, rhorenst@medicine.umaryland.edu Conflict of Interest Adam S. Fisch declares that he has no conflict of interest. Christina G. Perry declares that she has no conflict of interest. Sarah H. Stephens declares that she has no conflict of interest. Richard B. Horenstein declares that he has no conflict of interest. Alan R. Shuldiner declares that title= f1000research.9271.1 he has no conflict of interest.Fisch et al.Pagemedications consist of aspirin and clopidogrel, each and every of which influences blood hemostasis via different mechanisms. Marked inter-individual variation in response to these normally prescribed drugs have been well-documented and represent a important challenge to health-related practice [1 . Warfarin has a fairly narrow therapeutic index about which under-dosing may lead to recurrent thrombosis and over-dosing may possibly result in serious and life-threatening bleeding. Although newer agents which include dabigatran and rivaroxaban are now offered, physicians' familiarity with warfarin, its effectiveness when dosed adequately, and its low expense continue to produce it the anti-coagulant treatment of decision. Likewise, clopidogrel continues to become broadly prescribed because of its efficacy in the majority of individuals as well as its comparatively low cost, whilst newer anti-platelet medicati.Pt NIH-PA Author Manuscript NIH-PA Author ManuscriptTenee Lopez is presently an undergraduate student attending the University of Houston having a major in biochemistry. She started taking an interest in investigation although enrolled at the University of Texas at Brownsville through her freshman year and worked with Dr. Luis Colom in his Septo-Hippocampal Pathophysiology lab. Nevertheless it was not till she became a recipient of your NIDA Underrepresented Minorities 2011 Summer Research System that she started to concentrate on drug abuse investigation.