Values between left and right cerebellar nuclei in shams or in

Our results in sham rats reveal that basal expression of FosB is present in all deep cerebellar nuclei and that, among the deep nuclei, the DN contains the highest density of FosB immunopositive cells. The DN receives input from the more lateral parts of the cerebellar cortex while IN and FN receive input from the vermian cortex (for a review see Voogd [26]). Our data suggest that, in shams, the vermian cortex has a stronger inhibitory effect on its target nuclei than the cortex of the cerebellar hemispheres. Furthermore, Fos immunoreactivity has been described to occur in three subcellular expression patterns, that is, Version.76 Finally, reports from the Massachusetts Male solelynuclear, solely cytoplasmic, and both [27]. We found cells with nuclear FosB immunoreactivity as well as cells with cytoplasmic staining. This phenomenon has been described for the hippocampus, dentate gyrus, and amygdala by others [28] and appears to be present in the deep cerebellar nuclei as well. The implication of this finding is unclear as cytoplasmic Fos staining has been described weeks to months after a stimulus and has been related to damaged or dying.Values between left and right cerebellar nuclei in shams or in kindled animals; therefore values from both hemispheres were pooled. 3.1. FosB. FosB staining was not confined to the cell nucleus, as would be expected from a nuclear staining, but was seen in the cytoplasm as well (see Figure 1). This "FosBlike immunoreactivity" was almost exclusively found in the most lateral regions of the deep cerebellar nuclei and was observed in the DN in particular. Data represent mean ?SEM of 72 sections from 6 sham animals and 129 sections from 9 kindled animals.